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Buy Effexor Online! Venlafaxine (Effexor) is used for Treating depression. It may also be used for other conditions as determined by your doctor. Venlafaxine is a serotonin and norepinephrine reuptake inhibitor (SNRI). It works by restoring the balance of certain natural substances in the brain (serotonin and norepinephrine), which helps to improve certain mood problems.